Optical Microscopy Facility
This facility provides equipment and expertise to assist investigators in applying sophisticated optical microscopy techniques to their research. The facility director is Dr. Lynda Pierini, the facility manager is Leona Cohen-Gould, and overall supervision and guidance is provided by Dr. Frederick Maxfield.

Cell Screening Core Facility
This facility provides equipment and expertise to assist investigators in screening chemical compound libraries using cell-based assays and automated fluorescence microscopy. The facility director is Harold "Skip" Ralph and overall supervision and guidance is provided by Dr. Frederick R. Maxfield.

Fluorescence microscopy is a powerful tool for cell biology and biochemistry. It can provide information about subsets of cells and about structures, molecules and proteins within cells. In the past, the potential of this technique for providing the drug screener with this same wealth of information was limited by the inability to automate the process. Recent advances in instrumentation and software now make automated fluorescence imaging a practical tool in screening and drug discovery. Investigators at Weill Medical College now have access to this powerful research tool.

X-ray Crystallography Core Facility
This facility provides equipment and expertise to assist investigators in obtaining crystallographic structures of macromolecules and in analyzing and visualizing protein structures. Potential users should meet with the facility staff to discuss their individual project. The facility director is Ms. Jin Wu, and overall supervision is provided by Drs. Hao Wu and Frederick Maxfield.

Nuclear Magnetic Resonance Core Facility
NMR has become a powerful biological tool for the investigation of biomolecule structure, dynamics, and stability. A wide variety of experiments exist for analyzing biological molecules using NMR. Basic 1D and 2D applications can often be employed on small proteins and other compounds in a matter of hours to assess: composition, structure, sample purity, mutational effects and ligand binding interactions. More involved multidimensional NMR applications can be employed for protein structure determination and dynamics investigations. Facility directors are Drs. David Eliezer and Clay Bracken, and overall supervision is provided by Dr. Frederick Maxfield.